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Cerebrospinal fluid tau, Aß, and phosphorylated tau protein for the diagnosis of Alzheimer's disease
Author(s) -
Formichi Patrizia,
Battisti Carla,
Radi Elena,
Federico Antonio
Publication year - 2006
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.20602
Subject(s) - cerebrospinal fluid , tau protein , pathological , dementia , disease , alzheimer's disease , diagnostic accuracy , medicine , phosphorylation , pathology , biology , biochemistry
The diagnosis of AD is still largely based on exclusion criteria of secondary causes and other forms of dementia with similar clinical pictures, than the diagnostic accuracy of AD is low. Improved methods of early diagnosis are needed, particularly because drugs treatment is more effective in the early stages of the disease. Recent research focused the attention to biochemical diagnostic markers (biomarkers) and according to the proposal of a consensus group on biomarkers, three candidate CSF markers reflecting the pathological AD processes, have recently been identified: total tau protein (t‐tau), amyloid ß (1–42) protein (Aß 42 ), and tau protein phosphorylated at AD‐specific epitopes (p‐tau). Several articles report reduced CSF levels of Aß 42 and increased CSF levels of t‐tau and p‐tau in AD; the sensitivity and specificity of these data are able for discrimination of AD patients from controls. However, the specificity for other dementias is low. According to the literature analysis reported in the present review, we can conclude that the combination of the CSF markers and their ratios may significantly increase the specificity and the accuracy of AD diagnosis. © 2006 Wiley‐Liss, Inc.