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SWI/SNF: The crossroads where extracellular signaling pathways meet chromatin
Author(s) -
Simone Cristiano
Publication year - 2006
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.20514
Subject(s) - swi/snf , chromatin , chromatin remodeling , extracellular , signal transduction , microbiology and biotechnology , transcription factor , biology , nucleus , chromatin structure remodeling (rsc) complex , transcription (linguistics) , gene , genetics , computational biology , linguistics , philosophy
The coordinated expression of the genome in response to extracellular cues is ensured by enzymatic cascades signaling to the nucleus. These pathways generate chromatin modifications at specific loci controlling the transcription of signal‐dependent and tissue‐specific genes. The SWI/SNF chromatin remodeling complex offers the ideal surface for integrating these signals in the execution of diverse or even opposite biological programs. J. Cell. Physiol. 207: 309–314, 2006. © 2005 Wiley‐Liss, Inc.