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Role of cell‐cycle regulators in lung cancer
Author(s) -
Caputi Mario,
Russo Giuseppe,
Esposito Vincenzo,
Mancini Alessandro,
Giordano Antonio
Publication year - 2005
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.20424
Subject(s) - lung cancer , cell cycle , cancer research , lung , apoptosis , cancer , pathogenesis , cell growth , cell , biology , carcinoma , small cell lung carcinoma , medicine , pathology , immunology , small cell carcinoma , genetics
Lung cancer is the leading cause of cancer death worldwide. Histologically, 80% of lung cancers are classified as non‐small‐cell lung cancer (NSCLC), and the remaining 20% as small‐cell lung cancer (SCLC). Lung carcinoma is the result of molecular changes in the cell, resulting in the deregulation of pathways controlling normal cellular growth, differentiation, and apoptosis. This review summarizes some of the most recent findings about the role of cell‐cycle proteins in lung cancer pathogenesis and progression. © 2005 Wiley‐Liss, Inc.