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24p3 in differentiation of myeloid cells
Author(s) -
Liu Mingli,
Prisco Marco,
Drakas Robert,
Searles David,
Baserga Renato
Publication year - 2005
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.20400
Subject(s) - microbiology and biotechnology , myeloid cells , cellular differentiation , myeloid , biology , chemistry , genetics , cancer research , gene
24p3 is a secreted lipocalin that has been variously related to apoptosis, proliferation, and the neutrophil lineage of blood cells. We have investigated the expression of 24p3 mRNA and protein in myeloid cell lines induced to differentiate by insulin‐like growth factor 1 (IGF‐1) and the granulocytic‐colony simulating factor (G‐CSF). Both these growth factors, which cause myeloid cells to differentiate into granulocytes, induced a marked increase in the expression of both 24p3 protein and mRNA. The mRNA especially appeared early after the cells were induced with either IGF‐1 or G‐CSF, at a time when the cells were still proliferating and are morphologically undifferentiated. 24p3 can be considered an early marker of granulocytic differentiation. © 2005 Wiley‐Liss, Inc.