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Stem cells and pulmonary metamorphosis: New concepts in repair and regeneration
Author(s) -
Aliotta Jason M.,
Passero Michael,
Meharg Joseph,
Klinger James,
Dooner Mark S.,
Pimentel Jeffrey,
Quesenberry Peter J.
Publication year - 2005
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.20318
Subject(s) - stem cell , regeneration (biology) , haematopoiesis , biology , lung , immunology , adult stem cell , bone marrow , metamorphosis , microbiology and biotechnology , clinical uses of mesenchymal stem cells , neuroscience , pathology , medicine , endothelial stem cell , in vitro , genetics , botany , larva
Adult stem cells are likely to have much more versatile differentiation capabilities than once believed. Numerous studies have appeared over the past decade demonstrating the ability of adult stem cells to differentiate into a variety of cells from non‐hematopoietic organs, including the lung. The goal of this review is to provide an overview of the growth factors which are thought to be involved in lung development and disease, describe the cells within the lung that are believed to replace cells that have been injured, review the studies that have demonstrated the transformation of bone marrow‐derived stem cells into lung cells, and describe potential clinical applications with respect to human pulmonary disease. © 2005 Wiley‐Liss, Inc.