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Smart materials as scaffolds for tissue engineering
Author(s) -
Rosso Francesco,
Marino Gerardo,
Giordano Antonio,
Barbarisi Manlio,
Parmeggiani Domenico,
Barbarisi Alfonso
Publication year - 2005
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.20270
Subject(s) - extracellular matrix , tissue engineering , oligopeptide , plasmin , regeneration (biology) , disintegrin , matrix metalloproteinase , fibrin , synthetic biology , wound healing , microbiology and biotechnology , regenerative medicine , integrin , chemistry , materials science , nanotechnology , cell , biomedical engineering , computational biology , biology , biochemistry , metalloproteinase , peptide , enzyme , engineering , immunology
In this review, we focused our attention on the more important natural extracellular matrix (ECM) molecules (collagen and fibrin), employed as cellular scaffolds for tissue engineering and on a class of semi‐synthetic materials made from the fusion of specific oligopeptide sequences, showing biological activities, with synthetic materials. In particular, these new “intelligent” scaffolds may contain oligopeptide cleaving sequences specific for matrix metalloproteinases (MMPs), integrin binding domains, growth factors, anti‐thrombin sequences, plasmin degradation sites, and morphogenetic proteins. The aim was to confer to these new “intelligent” semi‐synthetic biomaterials, the advantages offered by both the synthetic materials (processability, mechanical strength) and by the natural materials (specific cell recognition, cellular invasion, and the ability to supply differentiation/proliferation signals). Due to their characteristics, these semi‐synthetic biomaterials represent a new and versatile class of biomimetic hybrid materials that hold clinical promise in serving as implants to promote wound healing and tissue regeneration. © 2005 Wiley‐Liss, Inc.