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Laminopathies: Involvement of structural nuclear proteins in the pathogenesis of an increasing number of human diseases
Author(s) -
Maraldi Nadir M.,
Squarzoni Stefano,
Sabatelli Patrizia,
Capanni Cristina,
Mattioli Elisabetta,
Ognibene Andrea,
Lattanzi Giovanna
Publication year - 2005
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.20217
Subject(s) - nuclear lamina , pathogenesis , biology , computational biology , genetics , nuclear protein , gene , immunology , transcription factor
Just at the beginning of the millennium the neologism laminopathies has been introduced in the scientific vocabulary. An exponential increase of interest on the subject started concomitantly, so that a formerly quite neglected group of rare human diseases is now widely investigated. This review will cover the history of the identification of the molecular basis for fourteen (since now) hereditary diseases arising from defects in genes that encode nuclear envelope and nuclear lamina‐associated proteins and will also consider the hypotheses that can account for the role of structural nuclear proteins in the pathogenesis of diseases affecting a wide spectrum of tissues. © 2004 Wiley‐Liss, Inc.