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Autocrine/paracrine regulation of keratinocyte urokinase plasminogen activator through the TGF‐α/EGF receptor
Author(s) -
Jensen Pamela J.,
Rodeck Ulrich
Publication year - 1993
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041550214
Subject(s) - autocrine signalling , paracrine signalling , keratinocyte , plasminogen activator , biology , transforming growth factor , epidermal growth factor , microbiology and biotechnology , tgf alpha , urokinase , growth factor , activator (genetics) , epidermis (zoology) , receptor , medicine , endocrinology , in vitro , anatomy , biochemistry , genetics
Transforming growth factor‐α (TGF‐α) appears to be an important autocrine/paracrine regulator of keratinocyte function. Not only does TGF‐α induce keratinocyte proliferation and migration in vitro, but it also has been detected in normal human epidermis and at elevated levels in hyperproliferative epidermis. In the present study we report that exogenous TGF‐α increases urokinase‐type plasminogen activator (uPA) in cultured human keratinocytes. Furthermore, in the absence of exogenous growth factors, the “basal” levels of uPA are decreased by an antagonist monoclonal antibody to the receptor shared by TGF‐α and epidermal growth factor (EGF). These results suggest that an endogenous factor serves as an autocrine/paracrine regulator of keratinocyte uPA. We hypothesize that activation of the TGF‐α/EGF receptor may coordinately regulate the keratinocyte response to cutaneous wounding, which includes enhanced uPA expression, migration, and proliferation. © 1993 Wiley‐Liss, Inc.