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Colony stimulating factor‐1 Is a negative regulator of the macrophage respiratory burst
Author(s) -
Phillips Wayne A.,
Hamilton John A.
Publication year - 1990
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041440203
Subject(s) - respiratory burst , macrophage , lipopolysaccharide , priming (agriculture) , tumor necrosis factor alpha , regulator , colony stimulating factor , granulocyte macrophage colony stimulating factor , immunology , stimulation , granulocyte macrophage colony stimulating factor receptor , biology , macrophage activating factor , macrophage colony stimulating factor , microbiology and biotechnology , cytokine , in vitro , biochemistry , endocrinology , haematopoiesis , botany , germination , stem cell , gene
Several cytokines have previously been shown to prime macrophages for enhanced release of oxygen radicals in response to subsequent stimulation. We now demonstrate that the presence of the macrophage‐specific colony stimulating factor‐1 (CSF‐1) inhibits the priming of murine macrophages by a variety of agents including tumor necrosis factor α, granulocyte/macrophage colony stimulating factor, interferon‐γ, and bacterial lipopolysaccharide. CSF‐1 is also able to reduce the respiratory burst in the absence of priming. Our results indicate that CSF‐1 is a potent negative regulator of the macrophage respiratory burst which acts to oppose the priming (enhancing) action of macrophage activating agents. We propose that CSF‐1 may have a potentially important and previously unrecognized, role as a Physiological regulator which restricts or terminates the activation of macrophages in order to prevent an uncontrolled inflammatory reaction.