Premium
Interleukin‐1 is a potent regulator of JE and KC gene expression in quiescent BALB/c fibroblasts
Author(s) -
Hall David J.,
Brownlee Clare,
Stiles Charles D.
Publication year - 1989
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041410123
Subject(s) - regulator , microbiology and biotechnology , gene expression , gene , biology , cancer research , chemistry , genetics
Interleukin‐1 alpha and beta are polypeptide hormones with a broad range of biological activities. Both interleukins are recognized by a receptor that has been characterized as a member of the immunoglobin superfamily. The interleukin‐1 receptor does not appear to be a tyrosine protein kinase. Moreover, the intracellular events that mediate the multiple interleukin‐1 responses are poorly understood. Here we show that the JE and KC genes, first isolated and characterized as platelet‐derived growth factor inducible in quiescent BALB/c‐3T3 fibroblasts, are induced by femtomolar concentrations of recombinant interleukin‐1 alpha (rlL‐1). The response of JE and KC to IL‐1 occurs at the transcriptional level. These observations suggest that an analysis of the JE and KC transcriptional response to rlL‐1 may aid in identifying elements involved in interleukin‐1‐mediated signal transduction.