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Differentiation of germ cells in seminiferous tubules transplanted to testes of germ cell‐deficient mice of W/W v and SI/SI d genotypes
Author(s) -
Kuroda Hideya,
Nakayama Hiroki,
Namiki Mikio,
Matsumoto Keishi,
Nishimune Yoshitake,
Kitamura Yukihiko
Publication year - 1989
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041390215
Subject(s) - spermatogenesis , biology , germ , germ cell , andrology , spermatocyte , testicle , ratón , immunology , anatomy , microbiology and biotechnology , endocrinology , genetics , meiosis , gene , medicine
(WB × C57BL/6)F 1 ‐ W/W (hereafter, WCB6F 1 ‐ SI/SI d ) mice are sterile due to the deficient spermatogenesis in the testes. The cause of deficient spermatogenesis in WBB6F 1 ‐ W/W mice is considered to be a defect in germ cells themselves, whereas that in WCB6F 1 ‐ SI/SI d mice is considered to be a defect in tissue environment necessary for differentiation of germ cells. Seminiferous tubules isolated from cryptorchid testes of C57BL/6‐+/+ mice were transplanted into the testes of WBB6F 1 ‐ W/W and WCB6F 1 ‐ SI/SI d mice to clarify that the extratubular environment of these mice was intact or not. Type A spermatogonia in the transplanted tubules normally differentiated into spermatids, suggesting that the extratubular environment is intact in both WBB6F 1 ‐ W/W and WCB6F 1 ‐ SI/SI d mice.