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Differential responses to growth factors by normal human mesothelial cultures from individual donors
Author(s) -
Lechner John F.,
LaVeck Moira A.,
Gerwin Brenda I.,
Matis Elizabeth A.
Publication year - 1989
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041390211
Subject(s) - mesothelial cell , pathogenesis , microbiology and biotechnology , biology , cell growth , cell culture , mesothelioma , cancer research , immunology , biochemistry , pathology , medicine , genetics
A significant interindividual variation in the growth rates is found in normal cultured human mesothelial (NHM) cells derived from different donors. This variation is observed when the mesothelial cells are incubated in medium containing serum and when the potencies of several separate growth factors are measured by using defined media. Depending on the donor, gamma‐interferon and interleukin‐2 can be toxic, have no effect, or stimulate the growth rate of NHM cells. Cultured NHM cells can be induced to multiply by growth factors that are released by activated macrophages. Thus, interindividual variation in NHM cell growth control could play a role in the pathogenesis of mesothelioma for a person exposed to asbestos.