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The effects of recombinant CSF‐1 on the blast cells of acute myeloblastic leukemia in suspension culture
Author(s) -
Miyauchi Jun,
Wang Chen,
Kelleher Colm A.,
Wong Gordon G.,
Clark Steven C.,
Minden Mark D.,
McCulloch Ernest A.
Publication year - 1988
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041350108
Subject(s) - acute myeloblastic leukemia , recombinant dna , haematopoiesis , precursor cell , leukemia , stem cell , cell culture , colony stimulating factor , granulocyte colony stimulating factor , cancer research , immunology , biology , in vitro , microbiology and biotechnology , chemotherapy , biochemistry , genetics , gene
Recombinant hemopoietic colony‐stimulating factors (CSFs), including GM‐CSF, G‐CSF and IL‐3, have been shown to be effective stimulators of both self‐renewal and terminal differentiation of blast stem cells in acute myeloblastic leukemia (AML). We have examined the activity of a fourth growth factor, recombinant CSF‐1 (or M‐CSF), on the growth of leukemic blasts in culture. CSF‐1 was found to be active on some, but not all, blast populations. In sensitive cells, CSF‐1 often stimulated the production of adherent blast cells incapable of division. This observation leads us to suggest that CSF‐1 may be useful in the treatment of selected cases of AML.