Premium
Interleukin‐1 regulation of hematopoietic growth factor production by human stromal fibroblasts
Author(s) -
Yang YuChung,
Tsai Shickwann,
Wong Gordon G.,
Clark Steven C.
Publication year - 1988
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041340217
Subject(s) - stromal cell , haematopoiesis , microbiology and biotechnology , biology , progenitor cell , growth factor , population , immunology , stem cell , cancer research , medicine , genetics , receptor , environmental health
The human stromal fibroblastoid cell strain designated ST‐1 represents a normal population of cells capable of supporting hematopoiesis in vitro. These cells constitutively elaborate hematopoietic growth factor activity into the medium and the level of production of this activity dramatically increases following stimulation of the cells with IL‐1. This enhanced production is due at least in part to increased expression of the genes for GM‐CSF, G‐CSF, and IL‐6, but not IL‐3. The IL‐1 treatment had little effect on the expression of M‐CSF, a factor made constitutively by the cells. These results are consistent with the model that hematopoiesis is regulated at least in part by constant short‐range interactions of humoral factors produced by stromal cells both with other types of stromal cells and with the hematopoietic progenitors.