Premium
Inhibition of cell surface ruffling and fluid‐phase pinocytosis by microinjection of anti‐ ras antibodies into living cells
Author(s) -
BarSagi D.,
McCormick F.,
Milley Robert J.,
Feramisco J. R.
Publication year - 1987
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041330414
Subject(s) - pinocytosis , membrane ruffling , microinjection , microbiology and biotechnology , antibody , cell , endocytosis , signal transduction , cell membrane , biology , chemistry , biochemistry , immunology , cytoskeleton
Fibroblasts transformed by ras oncogenes display enhanced cell surface ruffling and fluid‐phase pinocytotic activities. Microinjection of antibodies that specifically bind the ras proteins into these cells results in the inhibition of these two surface activities. The possible underlying biochemical basis of the influence of the ras proteins on membrane ruffling and pinocytosis and the potential relationship of these two biological activities to membrane signal transduction are discussed.