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Production of C5a antagonist by synovial and peritoneal tissue fibroblasts
Author(s) -
Matzner Yaacov,
Gavison Rivka,
Shlomai Zipora,
BenBassat Hanna,
Liebergal Meir,
Robinson Dwight R.,
Babior Bernard M.
Publication year - 1986
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041290213
Subject(s) - chemotaxis , mesothelium , fibroblast , antagonist , peritoneum , zymosan , inflammation , chemistry , immunology , microbiology and biotechnology , biology , medicine , pathology , receptor , biochemistry , in vitro
Abstract Fibroblasts grown from synovial and peritoneal tissues release into the medium an inhibitor of neutrophil chemotaxis. The inhibitor resembles the antagonist previously described in synovial and peritoneal fluids. It is a heat stable (56°C) protein of MW ∼40 kDa that counteracts the chemotactic activity of zymosan‐activated serum or purified C5a but not the peptide chemoattractant F‐met‐leu‐phe. No chemotactic inhibitor was detected in media from skin fibroblast cultures or in formal human sera. It is suggested that the inhibitor is produced locally by synovial and peritoneal fibroblasts and that it might play a role in the regulation of inflammation at sites lined with mesothelium.