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Retinoids stimulate the release of superoxide by neutrophils and change their morphology
Author(s) -
Badwey John A.,
Robinson John M.,
Curnutte John T.,
Karnovsky Morris J.,
Karnovsky Manfred L.
Publication year - 1986
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041270206
Subject(s) - superoxide , retinal , guinea pig , chemistry , superoxide radical , biophysics , microbiology and biotechnology , biochemistry , biology , endocrinology , enzyme
All‐trans‐retinal stimulated the release of superoxide by human and guinea pig neutrophils 63 ± 14 SD and 53 ± 5 SD nmol of O 2 − /min/10 7 cells, respectively. Superoxide release by unstimulated cells was negligible. All‐trans‐retinal also induced morphological changes (i.e., evaginations) in these cells. Other retinoids were effective in instigating these phenomena. The similarities of these effects to those instigated by cis‐unsaturated fatty acids (Badwey, J.A., et al., 1984, J. Biol. Chem., 259 :7870–7877) are discussed in light of possible mechanisms.