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Effects of pulsed electromagnetic field on growth and differentiation of embryonal carcinoma cells
Author(s) -
Akamine Takuya,
Muramatsu Hisako,
Hamada Hiroshi,
Sakou Takashi
Publication year - 1985
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041240212
Subject(s) - embryonal carcinoma , electromagnetic field , field (mathematics) , biology , microbiology and biotechnology , cellular differentiation , cancer research , chemistry , physics , mathematics , genetics , gene , pure mathematics , quantum mechanics
A murine embryonal carcinoma cell line (F9) was used to examine the effect of a pulsed electromagnetic field on the growth and differentiation of malignant cells. The cells can be induced to differentiate into parietal endodermal cells by treatment with retinoic acid. The pulsed electromagnetic field (1 Gauss and 10 Gauss) promoted the growth of embryonal carcinoma cells in both the presence and absence of retinoic acid. The pulsed electromagnetic field was also found to inhibit retionic acid‐induced differentiation, when the degree of differentiation was based on morphological criteria or on the production of plasminogen activator.