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The effect of translocations on the cellular myc gene in burkitt lymphomas
Author(s) -
Mitchell Kenneth F.,
Battey Jim,
Hollis Gregory F.,
Moulding Christopher,
Taub Rebecca,
Leder Philip
Publication year - 1984
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041210420
Subject(s) - chromosomal translocation , gene , biology , fusion gene , genetics , transformation (genetics) , cancer research , microbiology and biotechnology
Chromosomal translocations are found to be a characteristic feature of Burkitt lymphomas. Similar translocations are found in mouse plasmacytomas and both diseases involve interchanges between one of the immunoglobulin loci and DNA in the vicinity of the myc gene. The structure of the myc gene has been elucidated from studies on translocated versions of the gene. Activation of the myc gene may play a role in transformation by promoting growth of the cells bearing the rearranged chromosomes.