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Transforming growth factors released from Kirsten sarcoma virus transformed cells do not compete for epidermal growth factor membrane receptors
Author(s) -
Chua Chu Chang,
Geiman Deborah,
Ladda Roger L.
Publication year - 1983
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041170116
Subject(s) - epidermal growth factor , receptor , biology , growth factor , microbiology and biotechnology , epidermal growth factor receptor , virus , transforming growth factor , chemistry , virology , biochemistry
Kirsten murine sarcoma virus (KiMSV)‐transformed rat kidney cells (KNRK) release small polypeptides (M, 12,500–15,300) into the culture medium that are capable of stimulating normal rat kidney cells (NRK) to form colonies in soft agar. The transforming growth factors (TGFs) did not compete with epidermal growth factor (EGF) for its receptor and did not induce specific phosphorylation of EGF receptor on NRK cell membranes. These properties differ from the TGFs isolated by other investigators. Our data further establish the heterogeneity of the materials produced by transformed cells that induce transformation‐specific changes in normal cells.