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Mitogenic proteins of the 3T3 plasma membrane
Author(s) -
Lieberman Michael A.
Publication year - 1983
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041140112
Subject(s) - microbiology and biotechnology , chemistry , biophysics , biology
A mitogenic factor from 3T3 plasma membranes has been identified and partially characterized. The factor appears to be a peripheral membrane protein that can be released by mild trypsin, chymotrypsin, or plasmin treatment. This component is sensitive to heat and acid, and has a molecular weight in the range of 150,000–200,000 daltons as determined by gel filtration. A similar mitogenic activity has also been found on the membranes of both SV‐40‐transformed 3T3 cells and human fibroblasts. The factor appears to be distinct from all previously described mitogenic components.