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A new model system for studying the phosphatidylinositol cycle
Author(s) -
Monaco Marie E.,
Lippman Marc E.
Publication year - 1982
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041120122
Subject(s) - phosphatidylinositol , pi , vasopressin , chemistry , phospholipid , biochemistry , biology , endocrinology , medicine , microbiology and biotechnology , signal transduction , membrane
Abstract An early manifestation of the response of WRK‐1 rat mammary tumor cells to vasopressin is an increase in incorporation of ( 32 P)P i into phospholipids. Incorporation into all classes of phospholipids is stimulated; however, incorporation into phosphatidylinositol (PI) is increased to the greatest degree (3‐ to 10‐fold as compared with 1.3‐ to 2‐fold for the other phosholipids). Furthermore, increased incorporation into PI is accompanied by an increased rate of PI turnover; turnover rates of the other phospholipids are unaffected by vasopressin.