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Topography of the predifferentiation G D growth arrest state relative to other growth arrest states in the G 1 phase of the cell cycle
Author(s) -
Wille John J.,
Scott Robert E.
Publication year - 1982
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041120117
Subject(s) - cell cycle checkpoint , cell cycle , g1 phase , microbiology and biotechnology , cell growth , dna synthesis , restriction point , phase (matter) , chemistry , biology , apoptosis , dna , cell cycle progression , biochemistry , organic chemistry
The differentiation of 3T3 T proadipocytes is preceded by growth arrest at a state in the G 1 phase of the cell cycle (G D ) which is distinct from other G 1 growth arrest states including those induced by serum deprivation (G S ) or nutrient deprivation (G N ) (Scott et al., 1982). We now report that the G D , G S , and G N arrest states are also distinct in their topography in G 1 . This conclusion was derived from kinetic studies which measured the time required for cells arrested at various G 1 states to synthesize DNA and from studies on the ability of G D ‐, G S ‐, or G N ‐arrested cells to be converted from one arrest state to another in the absence of DNA synthesis. The results suggest that relative to the start of the G 1 phase of the cell cycle, the following arrest state topography exists: G D , G S , G N .