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Complement receptor phenotypes of culture‐derived murine macrophages
Author(s) -
Walker William S.,
Yen ShingErh
Publication year - 1982
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041100310
Subject(s) - phenotype , complement (music) , receptor , microbiology and biotechnology , biology , complement receptor , complement system , immunology , genetics , antibody , gene , complementation
Abstract The distribution of complement receptors CR1 and CR3 among macrophages derived from cultures of bone marrow, blood, and elicited or normal peritoneal cell population was studied. Cells and colonies from the first three sources had a common phenotype, CR1 + 3 −, whereas those from the noram peritoneal populations had either CR1 + 3 − or CR1 + 3 +. The former phenotype characterized spindle‐shaped as well as epithelial‐like macrophages; the latter was essentially restricted to colonies made up of the epithelioid cells. Both morphologic features and the CR phenotypes remained stable throughout the culture period. These phenotypic differences might be explaniend by the presence of at leas two clonally derived types of macrophages.