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Morphological transformation of cells induced by Kirsten sarcoma virus transforming factor is independent of serine protease
Author(s) -
Fulton R. Jerrold,
Kaplan Paul L.,
Hart David A.,
Ozanne Brad
Publication year - 1982
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041100113
Subject(s) - proteases , serine , serine protease , rous sarcoma virus , activator (genetics) , plasminogen activator , biology , virus , growth factor , microbiology and biotechnology , protease , biochemistry , enzyme , virology , gene , receptor , genetics
Reports from several laboratories have suggested that the virus transformed state may be maintained either by ectopically produced growth factors of alternatively by ectopically produced serine proteases including plasminogen activator. Here we show that the maintenance of transformation induced by Kirsten sarcoma virus induced growth factor(s) is independent of serine proteases in that (1) the factors are not themselves serine proteases, and (2) the growth factors do not induce the expression of detectable serine proteases or plasminogen activator.