Premium
Growth stimulation of bovine endothelial cells by vitamin A
Author(s) -
Melnykovych G.,
Clowes K. K.
Publication year - 1981
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041090209
Subject(s) - retinol , retinoic acid , retinyl acetate , stimulation , vitamin , retinyl palmitate , chemistry , medicine , retinal , endocrinology , biology , biochemistry , gene
Retinol at concentrations of 10 −6 and 10 −5 M stimulated growth of bovine aortic endothelial cells maintained in Eagle's MEM supplemented with delipidized serum. In addition to retinol, retinal, retinoic acid, and retinyl acetate were also growth stimulatory. At very low inoculum densities (4‐40 cells/cm 2 ) the growth promoting effect could be demonstrated only in the presence of conditioned medium from macrophage‐like culture P388D. When added to media containing whole (nondelipidized) serum, retinol was growth inhibitory at 10 −6 and 10 −5 M concentrations.