Premium
Collagen gels as a matrix for haemopoiesis
Author(s) -
Lanotte Michael,
Schor Seth,
Dexter T. Michael
Publication year - 1981
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041060213
Subject(s) - haematopoiesis , matrix (chemical analysis) , chemistry , microbiology and biotechnology , biology , stem cell , chromatography
We have shown that collagen gel can be used as a culture matrix for the cloning of granulocyte/macrophage progenitor cells (CFU‐C), the production of foci of marrow stromal cells and the maintenance of stem cell proliferation, differentiation and the production of CFU‐C. Since collagen is a physiological matrix and allows the simultaneous growth of a variety of cellular elements, the system should prove useful for examining the role of cell/cell interactions and regulatory molecules involved in haemopoiesis.