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Expression of the teratocarcinoma phenotype in hybrids between totipotent mouse teratocarcinoma and myeloma cells
Author(s) -
Correani Alessandro,
Croce Carlo M.
Publication year - 1980
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041050110
Subject(s) - teratocarcinoma , totipotent , biology , somatic cell , phenotype , microbiology and biotechnology , antigen , cell culture , cellular differentiation , genetics , gene
We have produced somatic cell hybrids between totipotent mouse teratocarcinoma and myeloma cells. These hybrids behave like the teratocar‐cinoma cell parent and express teratocarcinoma embryonal antigens. However, they also express the myeloma H‐2 antigens. The availability of these hybrids should make it possible to study the expression of already rearranged immunoglobulin genes during mouse development.