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Increased neurite development and plasminogen activator expression by exposure of human neuroblastoma cells to a plasminogen‐deficient growth medium
Author(s) -
Becherer P. R.,
Wachsman J. T.
Publication year - 1980
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041040108
Subject(s) - plasminogen activator , neurite , neuroblastoma , neuroblast , activator (genetics) , cell culture , tissue plasminogen activator , cell growth , microbiology and biotechnology , biology , chemistry , endocrinology , in vitro , biochemistry , neurogenesis , receptor , genetics
Growth of human neuroblastoma strain SK‐N‐SH in a plasminogen‐deficient medium results in about a 40% increase in the number of differentiated cells (cells with a neurite‐like process at least 50 μm in length) and about a five‐fold increase in the amount of plasminogen activator liberated per cell. Plasminogen deficiency has no effect on the growth rate of SK‐N‐SH cells. These results are consistent with the hypothesis that plasminogen activator is involved in neuroblast development.