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Membrane‐associated ribosomes in producing and nonproducing mouse myeloma cells
Author(s) -
Cieplinski William,
Scharff M. D.
Publication year - 1980
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041030310
Subject(s) - polysome , ribosome , antibody , biology , membrane protein , membrane , cell culture , protein biosynthesis , cell , microbiology and biotechnology , cell membrane , myeloma protein , biochemistry , chemistry , gene , rna , genetics
Abstract Mouse myeloma cell lines synthesize large amounts of immunoglobulin on their membrane‐associated polyribosomes. Variants which no longer synthesize immunoglobulins have been studied and shown to have the same number of tightly bound membrane‐associated polyribosomes as the parental cell lines. These polyribosomes are still active in the synthesis of nonimmunoglobulin proteins.