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Cholera toxin and analogues of cyclic AMP stimulate the growth of cultured human mammary epithelial cells
Author(s) -
TaylorPapadimitriou Joyce,
Purkis Patricia,
Fentiman Ian S.
Publication year - 1980
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041020306
Subject(s) - cholera toxin , intracellular , dna synthesis , cell growth , toxin , epidermal growth factor , biology , microbiology and biotechnology , endocrinology , medicine , chemistry , dna , biochemistry , receptor
The growth of human mammary epithelial cells is stimulated by cholera toxin and analogues of cyclic AMP, while the growth of breast derived fibroblasts is inhibited. These compounds have little effect on DNA synthesis in the absence of other mitogens but show a synergistic effect with serum and/or EGF. The results suggest that high intracellular levels of cyclic AMP in human mammary epithelial cells increase the growth response of the cell to mitogens.