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Concanavalin A induces an intraluminal alkalinization of thymocyte membrane vesicles
Author(s) -
Mikkelsen Ross B.,
SchmidtUllrich Rupert,
Wallach Donald F. H.
Publication year - 1980
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041020203
Subject(s) - concanavalin a , vesicle , thymocyte , membrane , reagent , biophysics , chemistry , biochemistry , biology , microbiology and biotechnology , immunology , in vitro , immune system , t cell
Weak acid distribution methods demonstrate that mitogenic levels of concanavalin A induce an intravesicular alkalinization of isolated thymocyte membrane vesicles. Experiments with chemical reagents that crosslink the high affinity concanavalin A receptor and extensive correlation with known cellular events suggest that a “membrane Bohr effect” may participate in the initiation of mitogenesis.