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A variant vascular endothelial cell line with altered growth characteristics
Author(s) -
McAuslan B. R.,
Reilly W.
Publication year - 1979
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041010309
Subject(s) - endothelial stem cell , cell culture , cell , microbiology and biotechnology , mutagenesis , wild type , biology , chemistry , mutation , biochemistry , in vitro , genetics , gene , mutant
A variant endothelial cell type was found to arise spontaneously from cultures of bovine aortal endothelial cells. This variant showed no contact inhibition and overgrew confluent cultures of wild‐type endothelial cells. Unlike other reported variants of this cell type produced by chemical mutagenesis or by withdrawal of polypeptide growth factor, this variant retained the capacity to synthesise factor VIII antigen, but showed no alteration from wild‐type in capacity to adsorb platelets. The variant also had an increased capacity to bind FITC‐conjugated con A to its surface.