Premium
Regulation of phosphodiesterase and ornithine decarboxylase by cAMP is cell cycle independent
Author(s) -
Kaiser Nurit,
Bourne Henry R.,
Insel Paul A.,
Coffino Philip
Publication year - 1979
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041010304
Subject(s) - ornithine decarboxylase , phosphodiesterase , enzyme , ornithine decarboxylase antizyme , cell cycle , microbiology and biotechnology , chemistry , cell growth , medicine , endocrinology , cell , biology , biochemistry
Cyclic AMP (cAMP) causes growth arrest in G 1 and induction of cAMP phosphodiesterase and decrease of ornithine decarboxylase in S49 mouse lymphoma cells. Dibutyryl cAMP treatment of partially synchronized cells causes similar changes in activities of both enzymes, regardless of position in the cell cycle. This suggests that cAMP regulation of these enzymes is not mediated by growth perturbation.