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A growth factor from spinal cord
Author(s) -
Jennings Thomas,
Jones R. David,
Lipton Allan
Publication year - 1979
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1041000208
Subject(s) - spinal cord , fibroblast growth factor , growth factor , central nervous system , polyacrylamide gel electrophoresis , endocrinology , medicine , biology , nerve growth factor , chemistry , biochemistry , neuroscience , receptor , enzyme
Mitogenic activity is present at a variety of sites in the central nervous system. A growth factor was purified from neonatal bovine spinal cord. It has a pI of 9.5‐9.8 and a molecular weight of about 11,000 daltons. Spinal cord growth factor is a basic polypeptide that is inactivated by extremely acid or basic conditions. Its mobility on SDS polyacrylamide gels suggests that this factor is different from pituitary FGF and brain FGF‐1.