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Steroid hormone toxicity in human fibroblasts does not correlate with high affinity receptor content
Author(s) -
Breslow J. L.,
Epstein J.,
Forbes G. B.,
Fontaine J. H.
Publication year - 1979
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040990309
Subject(s) - toxicity , receptor , hormone receptor , chemistry , hormone , microbiology and biotechnology , medicine , endocrinology , biology , cancer research , biochemistry , cancer , breast cancer , organic chemistry
Human diploid skin fibroblasts derived from normal individuals and those with the testicular feminization syndrome (TFM) have been shown to be killed to the same degree by dihydrotestosterone in spite of the absence of high affinity cellular androgen receptors in the TFM fibroblasts. Furthermore, several different normal fibroblast strains from various anatomical sites all showed similar amounts of androgen‐induced cytotoxicity even though their respective receptor contents differed by as much as ten‐fold. These results suggest that steroid‐induced cytotoxicity in human fibroblasts in not correlated with receptor content, unlike murine lymphoid cells in which the receptor content has been shown to be closely related to their ability to survive hormone exposure.