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Expression of malignancy in hybrids between normal and malignant cells
Author(s) -
Croce Carlo M.,
Barrick Joan,
Linnenbach Alban,
Koprowski Hilary
Publication year - 1979
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040990302
Subject(s) - ht1080 , fibrosarcoma , biology , somatic cell , ploidy , malignancy , phenotype , cancer research , hybrid , microbiology and biotechnology , immunology , genetics , gene , botany
Somatic cell hybrids between either normal human fibroblasts, phenotypically normal mouse fibroblasts or mouse peritoneal macrophages and HT1080 human diploid fibrosarcoma cells were studied for their ability to form tumors in nude mice. The results of this study indicate that tumorigenic behavior is expressed as a dominant trait in both human‐human and mouse‐human hybrid cells.