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Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro
Author(s) -
Diegelmann Robert F.,
Cohen I. Kelman,
McCoy Barbara J.
Publication year - 1979
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040980210
Subject(s) - keloid , fibroblast , in vitro , kinetics , chemistry , pathology , biochemistry , medicine , physics , quantum mechanics
Fibroblasts were isolated from keloid, normal skin, and normal scar and maintained in tissue culture for four passages. Growth kinetics were the same for all groups on days 2 through 12. However, the rate of collagen synthesis per fibroblast was greater in keloid derived cells than any controls at all growth phases. Keloid fibroblasts have an autonomous capacity to synthesize collagen at a significantly increased level in vitro, which may explain in part why these lesions are characterized by increased collagen deposition.