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Expression of transformation in cell hybrids. II. Nonsuppression of the transformed phenotype in hybrids between a chemically transformed and nontransformed derivatives of Balb/3T3
Author(s) -
Jha Krishna K.,
Cacciapuoti Janice,
Ozer Harvey L.
Publication year - 1978
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040970203
Subject(s) - clone (java method) , phenotype , biology , transformation (genetics) , hybrid , 3t3 cells , cell culture , microbiology and biotechnology , cell , genetics , gene , transfection , botany
Hybrid clones derived from a nitrosocarbaryl‐transformed Balb/3T3 cell line, Clone H, and a nontransformed cell line TH02 resemble the transformed parent in the clone morphology, higher saturation density, colony formation in medium with reduced serum concentration, growth in agarose and ability to form clones on Balb/3T3 monolayer. Results are discussed in the framework of genetic models which permit or require dominant mutations for the expression of transformed phenotype.