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Cytotoxicity of commonly used solvents at elevated temperatures
Author(s) -
Li Gloria C.,
Hahn George M.,
Shiu Esther C.
Publication year - 1977
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040930303
Subject(s) - cytotoxicity , solvent , chinese hamster , organic solvent , hamster , drug , chemistry , cell , biophysics , pharmacology , biochemistry , biology , in vitro , chemical engineering , microbiology and biotechnology , engineering
At 43°C (but not at 41°C), organic solvents used to dissolve water‐insoluble chemotherapeutic agents become themselves lethal to cells. This finding is not unique to Chinese hamster cells (HA‐1); mouse mammary sarcoma cells (EMT‐6) behave similarly. The solvent concentrations involved are in the range of those needed to make drug solutions. Hence experiments measuring drug‐cell interactions at elevated temperatures must include controls which independently measure solvent effects.