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Alteration of membrane electrical activity in rat myocardial cells following selective laser microbeam irradiation
Author(s) -
Kitzes Margarita,
Twiggs Gary,
Berns Michael W.
Publication year - 1977
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040930113
Subject(s) - microbeam , intracellular , contractility , membrane potential , laser , heart cells , membrane , cell , biophysics , cell membrane , chemistry , medicine , microbiology and biotechnology , endocrinology , biology , myocyte , biochemistry , optics , nuclear medicine , physics
Abstract Laser microirradiation of neonatal rat (1 to 2‐day‐old) ventricular cells in tissue culture results in overt changes in contractility. The intracellular study of their ongoing electrical activity prior to, during, and after laser microirradiation demonstrates that definite membrane alteration occurs concomitantly with induced contractile responses. Although all ventricular cells are depolarized by laser microirradiation, the ultimate response elicited seems to differ according to the type of myocardial cell impaled. Typical fibrillation potentials were induced mainly in pacemaker cells.