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Effect of calcitonin on the phosphorylation of non‐histones from cultured bone cells
Author(s) -
Bustos Sergio E.,
Schuster George S.,
Dirksen Thomas R.,
McKinney Ralph V.,
Lai David Y.L.
Publication year - 1977
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040920106
Subject(s) - phosphorylation , calcitonin , histone , microbiology and biotechnology , chemistry , endocrinology , biochemistry , biology , dna
32 P‐uptake into non‐histones from bone cell cultures was selectively stimulated in the presence of calcitonin. Comparison of the control and experimental radioactivity profiles of non‐histones fractionated by SDS gel electrophoresis showed that, in response to calcitonin stimulation, there was a 2‐ to 3‐fold increase in the specific activity associated with non‐histone proteins in the molecular weight range of 10,000 to 45,000 daltons while that of bands between 50,000 to 200,000 decreased.