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Embryonal carcinoma cells (and their somatic cell hybrids) are resistant to infection by the murine parvovirus MVM, which does infect other teratocarcinoma‐derived cell lines
Author(s) -
Miller Richard A.,
Ward David C.,
Ruddle Frank H.
Publication year - 1977
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040910309
Subject(s) - teratocarcinoma , biology , cell culture , embryonal carcinoma , somatic cell , parvoviridae , yolk sac , virology , parvovirus , electrofusion , virus , minute virus of mice , microbiology and biotechnology , embryo , cellular differentiation , genetics , materials science , gene , metallurgy
Minute virus of mice (MVM), a non‐defective parvovirus, has been shown to infect cultures of non‐pluripotent differentiated teratocarcinoma‐derived cells, but pluripotent (and “nullipotent”) embryonal carcinoma cells derived from the same teratocarcinoma resist MVN infection. Somatic cell hybrids between an embryonal carcinoma line and Friend erythroblastic leukemia cells are also resistant to MVM, even though Friend cells are susceptible. Among three blastocyst‐derived lines tested, only one, a parietal yolk sac cell line, resists MVM infection. These results suggest that teratocarcinoma cultures may provide useful systems in which to study the cellular factors which mediate susceptibility to this teratogenic and oncolytic virus.