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Pentose utilizing variants of Novikoff hepatoma cells: Modification of growth and morphological properties
Author(s) -
Hoffee Patricia,
Jargiello Patricia,
Zaner Linda,
Martin Judith
Publication year - 1977
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040910105
Subject(s) - pentose , ribose , biochemistry , cytochalasin b , arabinose , deoxyribose , biology , chemistry , xylose , cell , nucleic acid , fermentation , enzyme
A series of variant lines that utilize multiple pentoses for growth in place of glucose have been isolated from an 8‐azaguanine resistant line of Novikoff hepatoma cells (N1S167). These variants utilize for growth ribose, xylose, arabinose, and/or deoxyribose. The variants growing on pentose containing medium (a) exhibit a density dependent cessation of growth, (b) have a morphology change to a more flattened cell type, (c) become binucleated in the presence of cytochalasin B, and (d) show an altered sensitivity to trypsin treatment.