Cooperative binding of concanavalin a to thymocyte membrane vesicles augments uptake of α‐aminoisobutyrate | Zendy

SchmidtUllrich Rupert | Zendy; Mann Nathan D. | Zendy; Wallach Donald F. H. | Zendy

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Cooperative binding of concanavalin a to thymocyte membrane vesicles augments uptake of α‐aminoisobutyrate

Author(s) -

SchmidtUllrich Rupert,

Mann Nathan D.,

Wallach Donald F. H.

Publication year - 1976

Publication title -

journal of cellular physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 174

eISSN - 1097-4652

pISSN - 0021-9541

DOI - 10.1002/jcp.1040890442

Subject(s) - concanavalin a , lectin , vesicle , membrane , thymocyte , biology , chemistry , biophysics , biochemistry , immunology , in vitro , antigen , cd8

(1) Membrane vesicles from rabbit thymocytes accumulate α‐aminoisobutyrate in the presence of 0.1 M NaCl. Uptake is 1/2 maximal after about 2 min and reaches a plateau value (61 pmoles/mg protein) after 30 min. (2) Up to 25 μg concanavalin A/ml, binding of the lectin describes a sigmoid curve indicative of a cooperative process. (3) At lectin concentrations up to 8 μg/ml, lectin binding enhances the uptake of α‐aminoisobutyrate (maximally 30%).

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