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Why do tumor cells have a high aerobic glycolysis?
Author(s) -
Racker Efraim
Publication year - 1976
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040890429
Subject(s) - glycolysis , anaerobic glycolysis , atpase , chemistry , mechanism of action , biochemistry , metabolism , microbiology and biotechnology , enzyme , biology , in vitro
In Ehrlich ascites cells and several other tumors, the high aerobic glycolysis is maintained by generation of ADP and P i by the plasma membrane Na + K + ATPase. The high ATPase activity is caused by a defective pump that operates at a low efficiency. Studies of the mechanism of action of the Na + K + ATPase and other pump ATPases suggest several alternative mechanisms that might account for the decreased efficiency. The possibility of involvement of a proteolipid is under investigation.