Why do tumor cells have a high aerobic glycolysis? | Zendy

Racker Efraim | Zendy

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Why do tumor cells have a high aerobic glycolysis?

Author(s) -

Racker Efraim

Publication year - 1976

Publication title -

journal of cellular physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 174

eISSN - 1097-4652

pISSN - 0021-9541

DOI - 10.1002/jcp.1040890429

Subject(s) - glycolysis , anaerobic glycolysis , atpase , chemistry , mechanism of action , biochemistry , metabolism , microbiology and biotechnology , enzyme , biology , in vitro

In Ehrlich ascites cells and several other tumors, the high aerobic glycolysis is maintained by generation of ADP and P i by the plasma membrane Na + K + ATPase. The high ATPase activity is caused by a defective pump that operates at a low efficiency. Studies of the mechanism of action of the Na + K + ATPase and other pump ATPases suggest several alternative mechanisms that might account for the decreased efficiency. The possibility of involvement of a proteolipid is under investigation.

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