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Carbohydrate uptake by escherichia coli
Author(s) -
Kornberg Hans L.
Publication year - 1976
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040890409
Subject(s) - pep group translocation , phosphoenolpyruvate carboxykinase , sugar , galactose , biochemistry , carbohydrate , chemistry , sugar phosphates , phosphate , sucrose , biology , enzyme
In contrast to active transport, the uptake of carbohydrates via the phosphoenolpyruvate‐dependent phosphotransferase system (PTS) leads to the appearance in the cell of the sugar initially as a 1‐ or 6‐ phosphate ester. The components of the PTS that transfer phosphate to the sugar are not absolutely specific for any one sugar. Both their synthesis and their activity are controlled; in the latter, “fine” control, glucose‐6‐phosphate appears to play an important role. Studies of growth on, and uptake of, galactose by E.coli mutants devoid of components of the PTS and also devoid of active transport systems for galactose, suggest that proteins effecting facilitated diffusion of hexoses may be part of, or be closely associated with, the sugar‐specific components of the PTS.