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Endotoxin‐induced size change in bone marrow progenitors of granulocytes and macrophages
Author(s) -
Metcalf D.,
Wilson J. W.
Publication year - 1976
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040890304
Subject(s) - progenitor cell , bone marrow , macrophage , progenitor , biology , cell , granulocyte , immunology , cell cycle , microbiology and biotechnology , chemistry , stem cell , in vitro , biochemistry
Injection of 5 μg endotoxin to adult C 57 BL mice caused a marked increase in the sedimentation velocity of granulocytic and macrophage progenitor (colony‐forming) cells in the bone marrow. This change was maximal two days after injection and was not accompanied by corresponding changes in total marrow nucleated cell populations. The endotoxin‐induced shift was not dependent on the presence of the thymus but did not occur in mice challenged after preinjection with endotoxin. No changes in buoyant density, cell cycle status, pattern of differentiation and responsiveness of granulocytic and macrophage progenitor cells were observed after the injection of endotoxin. The increased sedimentation velocity of progenitor cells appears to indicate an increase in cell volume but the mechanisms involved have not been identified.