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Acetylcholine‐induced initiation of thymic lymphoblast DNA synthesis and proliferation
Author(s) -
Macmanus J. P.,
Boynton A. L.,
Whitfield J. F.,
Gillan D. J.,
Isaacs R. J.
Publication year - 1975
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040850218
Subject(s) - lymphoblast , acetylcholine , dna synthesis , in vitro , calcium , stimulation , dna , biology , cell growth , endocrinology , medicine , chemistry , microbiology and biotechnology , biochemistry , cell culture , genetics
Low (5 × 10 −9 M to 10 −7 M) acetylcholine concentrations cause a calcium‐independent stimulation of the initiation of DNA synthesis and proliferation of lymphoblasts which are part of rat thymocyte populations suspended in vitro. A much higher (5 × 10 −5 M) acetylcholine concentration also stimulates lymphoblast DNA synthesis and proliferation, but this action is calcium‐dependent. This proliferogenic response to acetylcholine is however not clearly mediated by either cyclic GMP or cyclic AMP.