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Heterogeneity of molecules with low molecular weight isolated from media conditioned by human leukocytes and capable of stimulating colony formation by human granulopoietic progenitor cells
Author(s) -
Price G. B.,
Senn J. S.,
McCulloch E. A.,
Till J. E.
Publication year - 1974
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040840307
Subject(s) - progenitor cell , peripheral blood , granulocyte , progenitor , human blood , chemistry , human bone , biology , biochemistry , microbiology and biotechnology , immunology , stem cell , in vitro , physiology
Molecules of low molecular weight, able to stimulate colony formation by human granulopoietic cells, were prepared from media conditioned by normal and leukemic human peripheral blood leukocytes. When molecules from these sources were studied, heterogeneity was observed in their ability, after radioiodination, to bind and suicide granulopoietic progenitors, in their radiolabelled tryptic digestion products and in their biological activity as stimulators of granulocyte colonies.